Journal: Blood Advances
Article Title: Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients
doi: 10.1182/bloodadvances.2020001776
Figure Lengend Snippet: sGPVI levels in trauma patients stratified by injury severity and coagulopathy. (A) sGPVI levels in patients with moderate (ISS ≤25; n = 13) and critical (ISS >25; n = 17) injuries. (B) sGPVI levels in patients with (n = 19) and without (n = 11) TIC. (C-D) Correlation between sGPVI levels and CA5 on ROTEM EXTEM (C) and plasma fibrinogen level (D). Bars indicate the mean with 95% CI. Student t test. *P < .05.
Article Snippet: Thromboelastometry Rotational thromboelastometry (ROTEM delta instrument; Rotem, Leipzig, Germany) was performed with citrated whole blood after addition of tissue factor in the presence (FIBTEM) and absence (EXTEM) of the actin polymerization inhibitor cytochalasin D. The platelet contribution to each parameter was calculated by subtracting the FIBTEM value from the EXTEM value, as previously described.
Techniques: Clinical Proteomics